佛波酯 PMA
品牌：Solarbio | 货号：P6741
商品货号：
商品品牌：
规格
基本售价：
选择规格
P6741-1mg
Solarbio
1mg
840.00元
P6741-5mg
Solarbio
5mg
2400.00元

别名
PMA,TPA,Phorbol ester,croton oil
英文名称
Phorbol 12-myristate 13-acetate
CAS
16561-29-8
分子式
C36H56O8
分子量
616.8
储存条件
-20°C
纯度
≥98%
单位
瓶
PMA（同义名：TPA）是一种广泛用于体内外实验的佛波酯(phorbol ester) PKC激活剂。PMA结合PKC(Ki =2.6 nM)并激活其功能，在细胞和组织中都呈现出极其广的抑制谱。PMA可以抑制Fas诱导的细胞凋亡，但又可以诱导HL-60细胞的凋亡。PMA是一种高效的肿瘤促进剂，可以促进小鼠皮肤瘤的形成。尽管PMA毒性较强，但是在人体内仍显示出抗白血病和抗中性白细胞减少的活性。

使用浓度： 
PMA的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。
Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.
CAS Number: 16561-29-8
Storage：-20°C.
Synonyms: PMA, TPA, Phorbol ester, croton oil.
Formulation: Crystalline solid
Chemical Name: 12-O-Tetradecanoylphorbol-13-acetate
Molecular Formula: C36H56O8
Molecular Weight：616.8
Purity:≥98%
Description:
Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.
Preparation and storage:
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 100mM..