Insphereo 3D InSight™ Liver Microtissues for Toxicology

Metabolic competency delivered in 3D

Are you looking for a more economical, more predictive in vitro model system for toxicity/DMPK, efficacy or disease modeling?  InSphero delivers assay-ready 3D InSightTM Liver Microtissues in 96-well format conveniently to your lab.  Upgrade your toxicity and safety assessment workflow with our long-lived hepatocyte and hepatocyte/non-parenchymal cell (NPC) co-culture microtissues.  Our 3D models go beyond the limitations of traditional 2D monolayer cell culture to provide:

• Viability >4 weeks
• Stable, inducible CYP expression
• Organotypic cytoarchitecture, including BSEP expression and functional bile salt secretion

Unparalleled convenience

InSphero 3D culture technology not only brings far greater assurance to in-house compound de-risking, but also offers the convenience of:

• Fixed production schedule for routine experimental timelines
• Reproducible manufacturing QC'd to ISO 9001:2008 standards to ensure continuity
• Convenient delivery in GravityTRAPTM assay plates, ready for dosing
• Multiple donor profiles available to meet specific needs

 Need results faster?  Let our 3D experts do the screening for you with 3D InSightTM Toxicology Services. 

3D InSightTM Liver Microtissues

InSphero liver microtissues are helping to define a new standard for in vitro liver models.  Learn more in our 3D InSightTM Liver Microtissue brochure.

Our 3D Liver Microtissue pipeline

The following 3D InSight™ Microtissues are in development. Please contact us for more information about availability and beta testing opportunities.

• Dog Liver Microtissues (beta test now)
• Minipig Liver Microtissues (beta test now)
• HepaRG Liver Microtissues (beta test now)
• Mouse Liver Microtissues
• Human Liver Microtissues from iPSC derived hepatocytes